Advances in Rickettsia pathogenicity Balraj, P. Renesto, P. /Raoult, Didier actin-based motility adhesins phagosomal escape PLD rickettsia T4SS One century after the first description of rickettsiae as human pathogens, the rickettsiosis remained poorly understood diseases. These microorganisms are indeed characterized by a strictly intracellular location which has, for long, prohibited their detailed study. Within the last ten years, the completion of the genome sequences of several strains allowed gaining a better knowledge about the molecular mechanisms involved in rickettsia pathogenicity. Here, we summarized available data concerning the critical steps of rickettsia-host cell interactions that should contribute to tissue injury and diseases, that is, adhesion, phagosomal escape, motility, and intracellular survival of the bacteria. 2009 text https://www.documentation.ird.fr/hor/fdi:010046181 fdi:010046181 Balraj P., Renesto P., Raoult Didier. Advances in Rickettsia pathogenicity. 2009, 1166, 94-105 EN