@article{fdi:010046111,
  title = {{A}ce-{I} duplication in {A}nopheles gambiae : a challenge for malaria control},
  author = {{D}jogb{\'e}nou, {L}uc and {L}abbe, {P}. and {C}handre, {F}abrice and {P}asteur, {N}. and {W}eill, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {I}nsecticide resistance is a rapid and recent evolutionary phenomenon with serious economic and public health implications. {I}n the mosquito {A}nopheles gambiae s.s., main vector of malaria, resistance to organophosphates and carbamates is mainly due to a single amino-acid substitution in acetylcholinesterase 1 ({AC}h{E}1). {T}his mutation entails a large fitness cost. {H}owever, a resistant duplicated allele of the gene encoding {AC}h{EI} (ace-1), potentially associated to a lower fitness cost, recently appeared in {A}n. gambiae. {M}ethods: {U}sing molecular phenotype data collected from natural populations from {W}est {A}frica, the frequency of this duplicated allele was investigated by statistical inference. {T}his method is based on the departure from {H}ardy-{W}einberg phenotypic frequency equilibrium caused by the presence of this new allele. {R}esults: {T}he duplicated allele, {A}g-ace-1({D}), reaches a frequency up to 0.65 in {I}vory {C}oast and {B}urkina {F}aso, and is potentially present in {B}enin. {A} previous study showed that {A}g-ace-1({D}), present in both {M} and {S} molecular forms in different {W}est {A}frica countries, was generated by a single genetic event. {T}his single origin and its present distribution suggest that this new allele is currently spreading. {C}onclusion: {T}he spread of this less costly resistance allele could represent a major threat to public health, as it may impede {A}n. gambiae control strategies, and thus increases the risk of malaria outbreaks.},
  keywords = {},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {8},
  numero = {},
  pages = {70},
  ISSN = {1475-2875},
  year = {2009},
  DOI = {10.1186/1475-2875-8-70},
  URL = {https://www.documentation.ird.fr/hor/fdi:010046111},
}