@article{fdi:010046101,
  title = {{M}ultiple origins and regional dispersal of resistant dhps in african {P}lasmodium falciparum malaria},
  author = {{P}earce, {R}. {J}. and {P}ota, {H}. and {E}vehe, {M}. {S}. {B}. and {B}â, {E}l {H}adj and {M}ombo-{N}goma, {G}. and {M}alisa, {A}. {L}. and {O}rd, {R}. and {I}nojosa, {W}. and {M}atondo, {A}. and {D}iallo, {D}. {A}. and {M}bacham, {W}. and van den {B}roek, {I}. {V}. and {S}warthout, {T}. {D}. and {G}etachew, {A}. and {D}ejene, {S}. and {G}robusch, {M}. {P}. and {N}jie, {F}. and {D}unyo, {S}. and {K}weku, {M}. and {O}wusu-{A}gyei, {S}. and {C}handramohan, {D}. and {B}onnet, {M}. and {G}uthmann, {J}. {P}. and {C}larke, {S}. and {B}arnes, {K}. {I}. and {S}treat, {E}. and {K}atokele, {S}. {T}. and {U}usiku, {P}. and {A}gboghoroma, {C}. {O}. and {E}legba, {O}. {Y}. and {C}iss{\'e}, {B}. and {A}-{E}lbasit, {I}. {E}. and {G}iha, {H}. {A}. and {K}achur, {S}. {P}. and {L}ynch, {C}. and {R}wakimari, {J}. {B}. and {C}handa, {P}. and {H}awela, {M}. and {S}harp, {B}. and {N}aidoo, {I}. and {R}oper, {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {A}lthough the molecular basis of resistance to a number of common antimalarial drugs is well known, a geographic description of the emergence and dispersal of resistance mutations across {A}frica has not been attempted. {T}o that end we have characterised the evolutionary origins of antifolate resistance mutations in the dihydropteroate synthase (dhps) gene and mapped their contemporary distribution. {M}ethods and {F}indings: {W}e used microsatellite polymorphism flanking the dhps gene to determine which resistance alleles shared common ancestry and found five major lineages each of which had a unique geographical distribution. {T}he extent to which allelic lineages were shared among 20 {A}frican {P}lasmodium falciparum populations revealed five major geographical groupings. {R}esistance lineages were common to all sites within these regions. {T}he most marked differentiation was between east and west {A}frican {P}. falciparum, in which resistance alleles were not only of different ancestry but also carried different resistance mutations. {C}onclusions: {R}esistant dhps has emerged independently in multiple sites in {A}frica during the past 10-20 years. {O}ur data show the molecular basis of resistance differs between east and west {A}frica, which is likely to translate into differing antifolate sensitivity. {W}e have also demonstrated that the dispersal patterns of resistance lineages give unique insights into recent parasite migration patterns.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {M}edicine},
  volume = {6},
  numero = {4},
  pages = {e1000055},
  ISSN = {1549-1277},
  year = {2009},
  DOI = {10.1371/journal.pmed.1000055},
  URL = {https://www.documentation.ird.fr/hor/fdi:010046101},
}