@article{fdi:010046052,
  title = {{E}lectrochemical impedance spectroscopy to study physiological changes affecting the red blood cell after invasion by malaria parasites},
  author = {{R}ibaut, {C}. and {R}eybier, {K}. and {R}eynes, {O}. and {L}aunay, {J}. and {V}alentin, {A}. and {F}abre, {P}. {L}. and {N}epveu, {F}ran{\c{c}}oise},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he malaria parasite, {P}lasmodium falciparum, invades human erythrocytes and induces dramatic changes in the host cell. {T}he idea of this work was to use {RBC} modified electrode to perform electrochemical impedance spectroscopy ({EIS}) with the aim of monitoring physiological changes affecting the erythrocyte after invasion by the malaria parasite. {I}mpedance cell-based devices are potentially useful to give insight into cellular behavior and to detect morphological changes. {T}he modelling of impedance plots ({N}yquist diagram) in equivalent circuit taking into account the presence of the cellular layer, allowed us pointing out specific events associated with the development of the parasite such as (i) strong changes in the host cell cytoplasm illustrated by changes in the film capacity, (ii) perturbation of the ionic composition of the host cell illustrated by changes in the film resistance, (iii) releasing of reducer (lactic acid or heme) and an enhanced oxygen consumption characterized by changes in the charge transfer resistance and in the {W}arburg coefficient characteristic of the redox species diffusion. {T}hese results show that the {RBC}-based device may help to analyze strategic events in the malaria parasite development constituting a new tool in antimalarial research.},
  keywords = {{P}lasmodium falciparum ; {R}ed blood cell ; {E}lectrochemical impedance spectroscopy},
  booktitle = {},
  journal = {{B}iosensors and {B}ioelectronics},
  volume = {24},
  numero = {8},
  pages = {2721--2725},
  ISSN = {0956-5663},
  year = {2009},
  DOI = {10.1016/j.bios.2008.12.018},
  URL = {https://www.documentation.ird.fr/hor/fdi:010046052},
}