Godoy P. auteur aut IRD Marsac D. auteur aut IRD Stefas E. auteur aut IRD Ferrer P. auteur aut IRD Tischler N. D. auteur aut IRD Pino K. auteur aut IRD Ramdohr P. auteur aut IRD Vial P. auteur aut IRD Valenzuela P. D. T. auteur aut IRD Ferres M. auteur aut IRD Veas Francisco auteur aut IRD Lopez-Lastra M. auteur aut IRD text journalArticle eng text/pdf born digital access Hantavirus cardiopulmonary syndrome (HCPS) is a highly pathogenic emerging disease (40% case fatality rate) caused by New World hantaviruses. Hantavirus infections are transmitted to humans mainly by inhalation of virus-contaminated aerosol particles of rodent excreta and secretions. At present, there are no antiviral drugs or immunotherapeutic agents available for the treatment of hantaviral infection, and the survival rates for infected patients hinge largely on early virus recognition and hospital admission and aggressive pulmonary and hemodynamic support. In this study, we show that Andes virus (ANDV) interacts with human apolipoprotein H (ApoH) and that ApoH-coated magnetic beads or ApoH-coated enzyme-linked immunosorbent assay plates can be used to capture and concentrate the virus from complex biological mixtures, such as serum and urine, allowing it to be detected by both immunological and molecular approaches. In addition, we report that ANDV-antigens and infectious virus are shed in urine of HCPS patients. specialized 052 83 10 5046-5055 2009 0022-538X https://www.documentation.ird.fr/hor/fdi:010046046 10.1128/jvi.02409-08 0022-538X [F B010046046] https://www.documentation.ird.fr/hor/fdi:010046046 https://www.documentation.ird.fr/intranet/publi/2009/05/010046046.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2009-06-08 2017-08-23 fdi:010046046 fre