Samleerat T. auteur aut IRD Thenin S. auteur aut IRD Jourdain Gonzague auteur aut IRD Ngo-Giang-Huong Nicole auteur aut IRD Moreau A. auteur aut IRD Leechanachai P. auteur aut IRD Ithisuknanth J. auteur aut IRD Pagdi K. auteur aut IRD Wannarit P. auteur aut IRD Sangsawang S. auteur aut IRD Lallemant Marc auteur aut IRD Barin F. auteur aut IRD Braibant M. auteur aut IRD text journalArticle eng text/pdf born digital access Mother-to-child transmission (MTCT) of HIV-1 provides a model for studying the role of passively acquired antibodies in preventing HIV infection. We determined the titers of neutralizing antibodies (NAbs) against six primary isolates of clades B and CRF01_AE in sera from 45 transmitting and 45 nontransmitting mothers matched for the main independent factors associated with MTCT in Thailand. A lower risk of MTCT, particularly for intrapartum transmission, was associated only with higher NAb titers against the CRF01_AE strain, MBA. The envelope glycoprotein of this strain showed an unusually long V2 domain of 63 amino acids, encoding six potential N-linked glycosylation sites. We provided experimental data indicating that the extended V2 domain contributed to the higher level of resistance to neutralization by mothers' sera in this strain. Taken together the data suggest that some primary isolates with specific properties may be useful indicators for identifying protective antibodies. specialized HIV Mother-to-child transmission Neutralizing antibodies 052 387 2 388-394 2009 0042-6822 https://www.documentation.ird.fr/hor/fdi:010046044 10.1016/j.virol.2009.02.024 0042-6822 [F B010046044] https://www.documentation.ird.fr/hor/fdi:010046044 https://www.documentation.ird.fr/intranet/publi/2009/05/010046044.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2009-06-08 2017-08-23 fdi:010046044 fre