@article{fdi:010046044,
  title = {{M}aternal neutralizing antibodies against a {CRF}01_{AE} primary isolate are associated with a low rate of intrapartum {HIV}-1 transmission},
  author = {{S}amleerat, {T}. and {T}henin, {S}. and {J}ourdain, {G}onzague and {N}go-{G}iang-{H}uong, {N}icole and {M}oreau, {A}. and {L}eechanachai, {P}. and {I}thisuknanth, {J}. and {P}agdi, {K}. and {W}annarit, {P}. and {S}angsawang, {S}. and {L}allemant, {M}arc and {B}arin, {F}. and {B}raibant, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{M}other-to-child transmission ({MTCT}) of {HIV}-1 provides a model for studying the role of passively acquired antibodies in preventing {HIV} infection. {W}e determined the titers of neutralizing antibodies ({NA}bs) against six primary isolates of clades {B} and {CRF}01_{AE} in sera from 45 transmitting and 45 nontransmitting mothers matched for the main independent factors associated with {MTCT} in {T}hailand. {A} lower risk of {MTCT}, particularly for intrapartum transmission, was associated only with higher {NA}b titers against the {CRF}01_{AE} strain, {MBA}. {T}he envelope glycoprotein of this strain showed an unusually long {V}2 domain of 63 amino acids, encoding six potential {N}-linked glycosylation sites. {W}e provided experimental data indicating that the extended {V}2 domain contributed to the higher level of resistance to neutralization by mothers' sera in this strain. {T}aken together the data suggest that some primary isolates with specific properties may be useful indicators for identifying protective antibodies.},
  keywords = {{HIV} ; {M}other-to-child transmission ; {N}eutralizing antibodies},
  booktitle = {},
  journal = {{V}irology},
  volume = {387},
  numero = {2},
  pages = {388--394},
  ISSN = {0042-6822},
  year = {2009},
  DOI = {10.1016/j.virol.2009.02.024},
  URL = {https://www.documentation.ird.fr/hor/fdi:010046044},
}