@article{fdi:010046041,
  title = {{M}ulti-micronutrient-fortified biscuits decreased prevalence of anemia and improved micronutrient status and effectiveness of deworming in rural vietnamese school children},
  author = {{T}ran, {T}. {N}. and {W}inichagoon, {P}. and {D}ijkhuizen, {M}. {A}. and {N}guyen, {C}. {K}. and {W}asantwisut, {E}. and {F}urr, {H}. and {W}ieringa, {F}rank},
  editor = {},
  language = {{ENG}},
  abstract = {{C}oncurrent micronutrient deficiencies are prevalent among {V}ietnamese school children. {A} school-based program providing food fortified with multiple micronutrients could be a cost-effective and sustainable strategy to improve health and cognitive function of school children. {H}owever, the efficacy of such an intervention may be compromised by the high prevalence of parasitic infestation. {T}o evaluate the efficacy of school-based intervention using multi-micronutrient-fortified biscuits with or without deworming on anemia and micronutrient status in {V}ietnamese schoolchildren, a randomized, double-blind, placebo-controlled trial was conducted among 510 primary schoolchildren, aged 6-8 y, in rural {V}ietnam. {A}lbendazole ({A}lb) (400 mg) or placebo was given at baseline. {N}onfortified or multi-micronutrient-fortified biscuits including iron (6 mg), zinc (5.6 mg), iodine (35 mu g), and vitamin {A} (300 mu g retinol equivalents) were given 5 d/wk for 4 me. {M}ulti-micronutrient fortification significantly improved the concentrations of hemoglobin (+1.87 g/{L}; 95% {C}l: 0.78, 2.96), plasma ferritin (+7.5 mu g/{L}; 95% {C}l: 2.8, 12.6), body iron (+0.56 mg/kg body weight; 95% {C}l: 0.29, 0.84), plasma zinc (+0.61 mu mol/{L}; 95% {C}l: 0.26, 0.95), plasma retinol (+0.041 mu mol/{L}; 95% {C}l: 0.001, 0.08), and urinary iodine (+22.49 mu mol/{L}; 95% {C}l: 7.68, 37.31). {F}ortification reduced the risk of anemia and deficiencies of zinc and iodine by >40%. {P}arasitic infestation did not affect fortification efficacy, whereas fortification significantly enhanced deworming efficacy, with the lowest reinfection rates in children receiving both micronutrients and {A}lb. {M}ulti-micronutrient fortification of biscuits is an effective strategy to improve the micronutrient status of {V}ietnamese schoolchildren and enhances effectiveness of deworming. {J}. {N}utr. 139: 1013-1021, 2009.},
  keywords = {},
  booktitle = {},
  journal = {{J}ournal of {N}utrition},
  volume = {139},
  numero = {5},
  pages = {1013--1021},
  ISSN = {0022-3166},
  year = {2009},
  DOI = {10.3945/jn.108.099754},
  URL = {https://www.documentation.ird.fr/hor/fdi:010046041},
}