Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES American Journal of Tropical Medicine and Hygiene 755-759 2008 fdi:010045376 ENG American Journal of Tropical Medicine and Hygiene 0002-9637 SP:000260945100025 5 https://www.documentation.ird.fr/hor/fdi:010045376 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers19-11/010045376.pdf 79 Horizon (IRD) We conducted a cross-sectional study of Chagas disease in five endemic areas in Argentina, Bolivia. Honduras, and Mexico to estimate the prevalence of Trypanosoma cruzi-specific antibodies in pregnant women, and to assess the use of a rapid test (Chagas Stat-Pak) to screen for T. cruzi infection ill the time of delivery. The prevalence of antibodies to T. cruzi measured by enzyme-linked immunosorbent assay (ELISA) in maternal blood was 5.5% (a range of 0.8-28.8% among the countries) in 2,495 women enrolled. Compared with ELISA in maternal blood samples, the Chagas Stat-Pak rapid test sensitivity and specificity in umbilical cord blood were 94.6% and 99.0%, respectively. These results show the ability for a rapid determination of the presence of T. cruzi-specific antibodies in umbilical cord blood as a pragmatic strategy to screen for infection in pregnant women. 052