@article{fdi:010044375,
  title = {{H}allazgos complementarios sobre la actividad antimalarica del azul de metileno = {C}omplementary findings on the antimalarial activity and toxicity of methylene blue},
  author = {{G}aravito, {G}. and {B}ertani, {S}. and {D}eharo, {E}ric},
  editor = {},
  language = {{ENG}},
  abstract = {{M}ethylene blue was reported as the first synthetic antimalarial by {E}hrlich in 1881. {I}t is currently no longer used for that purpose but it should be reconsidered since new economic alternatives are urgently needed in the arsenal of antimalarial drugs. {T}he antimalarial activity of methylene blue is investigated here in vivo against rodent malaria parasites. 15 mg/kg daily dose of methylene blue inhibits 50% of the erythrocytic parasite growth of {P}lasmodium berghei and {R} yoelii nigeriensis, while on hepatic stages of {P} yoelii yoelii {I}s almost inactive. {I}n cell culture experiments with the lymphoblast-like {BJAB} cells line, it is 20 times more cytotoxic than chloroquine. {N}evertheless, methylene blue shows a similar selectivity index as chloroquine against strains of different level of sensitivity of {P}.falciparum original from different geographical areas.},
  keywords = {{A}ntimalarials ; {P}lasmodium ; {M}alaria ; {M}ethylene blue},
  booktitle = {},
  journal = {{V}itae - {R}evista de la {F}acultad de {Q}uimica {F}armaceutica},
  volume = {15},
  numero = {1},
  pages = {91--95},
  ISSN = {0121-4004},
  year = {2008},
  URL = {https://www.documentation.ird.fr/hor/fdi:010044375},
}