Roumy V. auteur aut IRD Fabre N. auteur aut IRD Portet B. auteur aut IRD Bourdy Geneviève auteur aut IRD Acebey L. auteur aut IRD Vigor C. auteur aut IRD Valentin A. auteur aut IRD Moulis C. auteur aut IRD text journalArticle eng text/pdf born digital access Tapirira guianensis is a common tree used in traditional medicine in French Guiana against several infectious diseases (malaria, leishmaniasis, bacteria, etc.). The bioassay-guided purification of CH2Cl2 bark extract led to the isolation of four cyclic alkyl polyol derivatives: 4,6,2'-trihydroxy-6-[10'(Z)-heptadecenyl]-1-cyclohexen-2-one (1a), 1,4,6-trihydroxy-1,2'-epoxy-6-[10'(Z)-heptadecenyl]-2-cyclohexene (1b), 1,4,5,2'-tetrahydroxy-1-[10'(Z)-heptadecenyl]-2-cyclohexene (2), and 1,3,4,6-tetrahydroxy-1,2'-epoxy-6-[10'(Z)-heptadecenyl]-cyclohexane (3). The structures were established on the basis of ID and 2D NMR analyses. The anti-leishmanial, anti-plasmodial, anti-bacterial (on Staphylococcus aureus, Staphylococcus epidermidis and Escherichia coli), and anti-fungal (on Candida albicans) activities of the extracts and of these original compounds were evaluated. Two showed medicinal interest supporting the traditional uses of the plant. The structures were established through spectral analyses of the isolates and their derivatives. specialized Tapirira guianensis Aubl Anacardiaceae Cyclic alkyl polyol derivatives Anti-plasmodial Anti-leishmanial Anti-bacterial Plasmodium falciparum Leishmania amazonensis 076 70 2 305-311 2009 0031-9422 https://www.documentation.ird.fr/hor/fdi:010044342 10.1016/j.phytochem.2008.10.003 0031-9422 [F B010044342] https://www.documentation.ird.fr/hor/fdi:010044342 https://www.documentation.ird.fr/intranet/publi/2009/04/010044342.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2009-05-13 2017-08-23 fdi:010044342 fre