Marti G. auteur aut IRD Eparvier V. auteur aut IRD Moretti Christian auteur aut IRD Susplugas S. auteur aut IRD Prado S. auteur aut IRD Grellier P. auteur aut IRD Retailleau P. auteur aut IRD Gueritte F. auteur aut IRD Litaudon M. auteur aut IRD text journalArticle eng text/pdf born digital access In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The methanol extract obtained from the latex of Moronobea coccinea exhibited a strong antiplasmodial activity (95% at 10 mu g/ml). The phytochemical investigation of this extract led to the isolation of eleven polycyclic polyprenylated acylphloroglucinols (PPAPs), from which eight showed potent antiplasmodial activity with IC50 ranged from 3.3 mu M to 37.2 mu M. specialized Moronobea coccinea Clusiaceae Benzophenone Coccinone Antiplasmodial 076 70 1 75-85 2009 0031-9422 https://www.documentation.ird.fr/hor/fdi:010044322 10.1016/j.phytochem.2008.10.005 0031-9422 [F B010044322] https://www.documentation.ird.fr/hor/fdi:010044322 https://www.documentation.ird.fr/intranet/publi/2009/03/010044322.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2009-04-08 2017-08-23 fdi:010044322 fre