Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Phytochemistry 75-85 Moronobea coccinea Clusiaceae Benzophenone Coccinone Antiplasmodial 2009 fdi:010044322 ENG Phytochemistry 0031-9422 ISI:000264235800009 1 10.1016/j.phytochem.2008.10.005 https://www.documentation.ird.fr/hor/fdi:010044322 https://www.documentation.ird.fr/intranet/publi/2009/03/010044322.pdf 70 Horizon (IRD) In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The methanol extract obtained from the latex of Moronobea coccinea exhibited a strong antiplasmodial activity (95% at 10 mu g/ml). The phytochemical investigation of this extract led to the isolation of eleven polycyclic polyprenylated acylphloroglucinols (PPAPs), from which eight showed potent antiplasmodial activity with IC50 ranged from 3.3 mu M to 37.2 mu M. 076 US084