%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Marti, G.
%A Eparvier, V.
%A Moretti, Christian
%A Susplugas, S.
%A Prado, S.
%A Grellier, P.
%A Retailleau, P.
%A Gueritte, F.
%A Litaudon, M.
%T Antiplasmodial benzophenones from the trunk latex of Moronobea coccinea (Clusiaceae)
%D 2009
%L fdi:010044322
%G ENG
%J Phytochemistry
%@ 0031-9422
%K Moronobea coccinea ; Clusiaceae ; Benzophenone ; Coccinone ; Antiplasmodial
%M ISI:000264235800009
%N 1
%P 75-85
%R 10.1016/j.phytochem.2008.10.005
%U https://www.documentation.ird.fr/hor/fdi:010044322
%> https://www.documentation.ird.fr/intranet/publi/2009/03/010044322.pdf
%V 70
%W Horizon (IRD)
%X In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The methanol extract obtained from the latex of Moronobea coccinea exhibited a strong antiplasmodial activity (95% at 10 mu g/ml). The phytochemical investigation of this extract led to the isolation of eleven polycyclic polyprenylated acylphloroglucinols (PPAPs), from which eight showed potent antiplasmodial activity with IC50 ranged from 3.3 mu M to 37.2 mu M.
%$ 076