@article{fdi:010044322, title = {{A}ntiplasmodial benzophenones from the trunk latex of {M}oronobea coccinea ({C}lusiaceae)}, author = {{M}arti, {G}. and {E}parvier, {V}. and {M}oretti, {C}hristian and {S}usplugas, {S}. and {P}rado, {S}. and {G}rellier, {P}. and {R}etailleau, {P}. and {G}ueritte, {F}. and {L}itaudon, {M}.}, editor = {}, language = {{ENG}}, abstract = {{I}n an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of {P}lasmodium falciparum ({F}c{B}1) was undertaken on sixty plant extracts collected in {F}rench {G}uiana. {T}he methanol extract obtained from the latex of {M}oronobea coccinea exhibited a strong antiplasmodial activity (95% at 10 mu g/ml). {T}he phytochemical investigation of this extract led to the isolation of eleven polycyclic polyprenylated acylphloroglucinols ({PPAP}s), from which eight showed potent antiplasmodial activity with {IC}50 ranged from 3.3 mu {M} to 37.2 mu {M}.}, keywords = {{M}oronobea coccinea ; {C}lusiaceae ; {B}enzophenone ; {C}occinone ; {A}ntiplasmodial}, booktitle = {}, journal = {{P}hytochemistry}, volume = {70}, numero = {1}, pages = {75--85}, ISSN = {0031-9422}, year = {2009}, DOI = {10.1016/j.phytochem.2008.10.005}, URL = {https://www.documentation.ird.fr/hor/fdi:010044322}, }