Holzmuller Philippe auteur aut IRD Grébaut Pascal auteur aut IRD Peltier J. B. auteur aut IRD Brizard Jean-Paul auteur aut IRD Perrone T. auteur aut IRD Gonzatti M. auteur aut IRD Bengaly Z. auteur aut IRD Rossignol M. auteur aut IRD Aso P. M. auteur aut IRD Vincendeau P. auteur aut IRD Cuny Gérard auteur aut IRD Boulangé A. auteur aut IRD Frutos R. auteur aut IRD text journalArticle eng text/pdf born digital access Animal trypanosomosis is one of the most severe constraints to agricultural development in sub-Saharan Africa and is also an important disease of livestock in Latin America and Asia. The causative agents are various species of protozoan parasites belonging to the genus Trypanosoma, among which T. congolense and T. evansi are the major pathogenic species. The extracellular position of trypanosomes obliges us to consider both the parasite and its excreted/secreted factors in the course of the physiopathologic process. The advent of proteomics led us to propose a comparative approach of the proteome (i.e., the whole parasite content) and the secretome (i.e., naturally excreted/secreted molecules) of T. congolense and T. evansi with particular attention to common and specific molecules between strains of differing virulence and pathogenicity. The molecular identification of differentially expressed trypanosome molecules correlated with either the virulence process or the pathogenicity will provide new potential molecular targets for improved field diagnosis and chemotherapy of animal trypanosomosis. specialized animal trypanosomosis secretome virulence pathogenicity proteomics diagnosis drug targets 080 1149 337-342 2008 0077-8923 https://www.documentation.ird.fr/hor/fdi:010044241 10.1196/annals.1428.097 0077-8923 [F B010044241] https://www.documentation.ird.fr/hor/fdi:010044241 https://www.documentation.ird.fr/intranet/publi/2009/02/010044241.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2009-03-06 2017-08-23 fdi:010044241 fre