Holzmuller Philippe auteur aut IRD Grébaut Pascal auteur aut IRD Brizard Jean-Paul auteur aut IRD Berthier D. auteur aut IRD Chantal I. auteur aut IRD Bossard G. auteur aut IRD Bucheton Bruno auteur aut IRD Vezilier F. auteur aut IRD Chuchana P. auteur aut IRD Bras Goncalves Rachel auteur aut IRD Lemesre Jean-Loup auteur aut IRD Vincendeau P. auteur aut IRD Cuny Gérard auteur aut IRD Frutos R. auteur aut IRD Biron D. G. auteur aut IRD text journalArticle eng text/pdf born digital access Many scientists working on pathogens (viruses, bacteria, fungi, parasites) are betting heavily on data generated by longitudinal genomic-transcriptomic-proteomic studies to explain biochemical host-vector-pathogen interactions and thus to contribute to disease control. Availability of genome sequences of various organisms, from viruses to complex metazoans, led to the discovery of the functions of the genes themselves. The postgenomic era stimulated the development of proteomic and bioinformatics tools to identify the locations, functions, and interactions of the gene products in tissues and/or cells of living organisms. Because of the diversity of available methods and the level of integration they promote, proteomics tools are potentially able to resolve interesting issues specific not only to host-vector-pathogen interactions in cell immunobiology, but also to ecology and evolution, population biology, and adaptive processes. These new analytical tools, as all new tools, contain pitfalls directly related to experimental design, statistical treatment, and protein identification. Nevertheless, they offer the potency of building large protein-protein interaction networks for in silica, analysis of novel biological entities named "interactomes," a way of modeling host-vector-pathogen interactions to define new interference strategies. specialized host-vector-pathogen interactions proteomics interactome modeling 052 020 1149 66-70 2008 0077-8923 https://www.documentation.ird.fr/hor/fdi:010044238 10.1196/annals.1428.061 0077-8923 [F B010044238] https://www.documentation.ird.fr/hor/fdi:010044238 https://www.documentation.ird.fr/intranet/publi/2009/02/010044238.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2009-03-06 2017-08-23 fdi:010044238 fre