@article{fdi:010044228,
  title = {{A}nti-leishmanial and structure-activity relationship of ring substituted 3-phenyl-1-(1,4-di-{N}-oxide quinoxalin-2-yl)-2-propen-1-one derivatives},
  author = {{B}urguete, {A}. and {E}stevez, {Y}. and {C}astillo, {D}. and {G}onzalez, {G}. and {V}illar, {R}. and {S}olano, {B}. and {V}icente, {E}. and {S}ilanes, {S}. {P}. and {A}ldana, {I}. and {M}onge, {A}. and {S}auvain, {M}ichel and {D}eharo, {E}ric},
  editor = {},
  language = {{ENG}},
  abstract = {{A} series of ring substituted 3-phenyl-1-(1,4-di-{N}-oxide quinoxalin-2-yl)-2-propen-1-one derivatives were synthesized and tested for in vitro leishmanicidal activity against amastigotes of {L}eishmania amazonensis in axenical cultures and murine infected macrophages. {S}tructure-activity relationships demonstrated the importance of a radical methoxy at position {R}-3', {R}-4' and {R}-5'. (2{E})-3-(3,4,5-trimethoxy-phenyl)-1-(3,6,7-trimethyl-1,4-dioxy-quinoxalin -2- yl)-propenone was the most active. {C}ytotoxicity on macrophages revealed that this product was almost six times more active than toxic.},
  keywords = {quinoxaline ; anti-leishmanial ; structure-activity ; {L}eishmaniasis},
  booktitle = {},
  journal = {{M}emorias do {I}nstituto {O}swaldo {C}ruz},
  volume = {103},
  numero = {8},
  pages = {778--780},
  ISSN = {0074-0276},
  year = {2008},
  URL = {https://www.documentation.ird.fr/hor/fdi:010044228},
}