@article{fdi:010044159,
  title = {{CCR}5 polymorphism and plague resistance in natural populations of the black rat in {M}adagascar},
  author = {{T}ollenaere, {C}. and {R}ahalison, {L}. and {R}anjalahy, {M}. and {R}ahelinirina, {S}. and {D}uplantier, {J}ean-{M}arc and {B}rouat, {C}arine},
  editor = {},
  language = {{ENG}},
  abstract = {{M}adagascar remains one of the world's largest plague foci. {T}he black rat, {R}attus rattus, is the main reservoir of plague in rural areas. {T}his species is highly susceptible to plague in plague-free areas (low-altitude regions), whereas rats from the plague focus areas (central highlands) have evolved a disease-resistance polymorphism. {W}e used the candidate gene {CCR}5 to investigate the genetic basis of plague resistance in {R}. rattus. {W}e found a unique non-synonymous substitution ({H}184{R}) in a functionally important region of the gene. {W}e then compared (i) {CCR}5 genotypes of dying and surviving plague-challenged rats and (ii) {CCR}5 allelic frequencies in plague focus and plague-free populations. {O}ur results suggested a higher prevalence of the substitution in resistant animals compared to susceptible individuals, and a tendency for higher frequencies in plague focus areas compared to plague-free areas. {T}herefore, the {CCR}5 polymorphism may be involved in {M}alagasy black rat plague resistance. {CCR}5 and other undetermined plague resistance markers may provide useful biological information about host evolution and disease dynamics.},
  keywords = {{I}nfectious disease resistance ; {Y}ersinia pestis ; {C}hemokine receptor ; {C}andidate gene ; {I}mmunogenetics},
  booktitle = {},
  journal = {{I}nfection {G}enetics and {E}volution},
  volume = {8},
  numero = {6},
  pages = {891--897},
  ISSN = {1567-1348},
  year = {2008},
  DOI = {10.1016/j.meegid.2008.07.005},
  URL = {https://www.documentation.ird.fr/hor/fdi:010044159},
}