@article{fdi:010044067,
  title = {{D}ynamics of multiple insecticide resistance in the malaria vector {A}nopheles gambiae in a rice growing area in {S}outh-{W}estern {B}urkina {F}aso - art. no. 188},
  author = {{D}abir{\'e}, {K}. {R}. and {D}iabat{\'e}, {A}. and {D}jogb{\'e}nou, {L}uc and {O}uari, {A}. and {N}'{G}uessan, {R}. and {O}u{\'e}draogo, {J}. {B}. and {H}ougard, {J}ean-{M}arc and {C}handre, {F}abrice and {B}aldet, {T}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {I}nsecticide resistance of the main malaria vector, {A}nopheles gambiae, has been reported in south-western {B}urkina {F}aso, {W}est {A}frica. {C}ross-resistance to {DDT} and pyrethroids was conferred by alterations at site of action in the sodium channel, the {L}eu-{P}he kdr mutation; resistance to organophosphates and carbamates resulted from a single point mutation in the oxyanion hole of the acetylcholinesterase enzyme designed as ace-1({R}). {M}ethods: {A}n entomological survey was carried out during the rainy season of 2005 at {V}allee du {K}ou, a rice growing area in south-western {B}urkina {F}aso. {A}t the {V}allee du {K}ou, both insecticide resistance mechanisms have been previously described in the {M} and {S} molecular forms of {A}n. gambiae. {T}his survey aimed i) to update the temporal dynamics and the circumsporozoite infection rate of the two molecular forms {M} and {S} of {A}n. gambiae ii) to update the frequency of the {L}eu-{P}he kdr mutation within these forms and finally iii) to investigate the occurrence of the ace-1({R}) mutation. {M}osquitoes collected by indoor residual collection and by human landing catches were counted and morphologically identified. {S}pecies and molecular forms of {A}n. gambiae, ace-1({R}) and {L}eu-{P}he kdr mutations were determined using {PCR} techniques. {T}he presence of the circumsporozoite protein of {P}lasmodium falciparum was determined using {ELISA}. {R}esults: {A}nopheles gambiae populations were dominated by the {M} form. {H}owever the {S} form occurred in relative important proportion towards the end of the rainy season with a maximum peak in {O}ctober at 51%. {S}porozoite rates were similar in both forms. {T}he frequency of the {L}eu{P}he kdr mutation in the {S} form reached a fixation level while it is still spreading in the {M} form. {F}urthermore, the ace-1({R}) mutation prevailed predominately in the {S} form and has just started spreading in the {M} form. {T}he two mutations occurred concomitantly both in {M} and {S} populations. {C}onclusion: {T}hese results showed that the {V}allee du {K}ou, a rice growing area formerly occupied mainly by {M} susceptible populations, is progressively colonized by {S} resistant populations living in sympatry with the former. {A}s a result, the distribution pattern of insecticide resistance mutations shows the occurrence of both resistance mechanisms concomitantly in the same populations. {T}he impact of multiple resistance mechanisms in {M} and {S} populations of {A}n. gambiae on vector control measures against malaria transmission, such as insecticide-treated nets ({ITN}s) and indoor residual spraying ({IRS}), in this area is discussed.},
  keywords = {},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {7},
  numero = {},
  pages = {},
  ISSN = {1475-2875},
  year = {2008},
  DOI = {10.1186/1475-2875-7-188},
  URL = {https://www.documentation.ird.fr/hor/fdi:010044067},
}