Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES International Journal of Antimicrobial Agents 344-348 Statins Prevention Rickettsioses Rickettsia conorii 2008 fdi:010044029 ENG International Journal of Antimicrobial Agents 0924-8579 ISI:000258992300010 4 10.1016/j.ijantimicag.2008.04.027 https://www.documentation.ird.fr/hor/fdi:010044029 https://www.documentation.ird.fr/intranet/publi/2008/10/010042805.pdf 32 Horizon (IRD) Recent data suggest that statins may have a beneficial effect during sepsis. In this study, we tested the effect of lovastatin and pravastatin on the cellular culture of Rickettsia conorii using a quantitative plaque assay model associated with an original image analysis algorithm. Statins added at the time of infection did not modify plaque formation, whereas pre-incubation with statins for 48 h resulted in a significant 30-68% plaque reduction, depending on the tested compounds and doses. These preliminary findings raise the hypothesis that statins may prevent or moderate rickettsial disease in exposed people. 050 ; 052 UR198