%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Botelho-Nevers, E.
%A Rolain, J. M.
%A Espinosa, L.
%A Raoult, Didier
%T Statins limit Rickettsia conorii infection in cells
%D 2008
%L fdi:010044029
%G ENG
%J International Journal of Antimicrobial Agents
%@ 0924-8579
%K Statins ; Prevention ; Rickettsioses ; Rickettsia conorii
%M ISI:000258992300010
%N 4
%P 344-348
%R 10.1016/j.ijantimicag.2008.04.027
%U https://www.documentation.ird.fr/hor/fdi:010044029
%> https://www.documentation.ird.fr/intranet/publi/2008/10/010042805.pdf
%V 32
%W Horizon (IRD)
%X Recent data suggest that statins may have a beneficial effect during sepsis. In this study, we tested the effect of lovastatin and pravastatin on the cellular culture of Rickettsia conorii using a quantitative plaque assay model associated with an original image analysis algorithm. Statins added at the time of infection did not modify plaque formation, whereas pre-incubation with statins for 48 h resulted in a significant 30-68% plaque reduction, depending on the tested compounds and doses. These preliminary findings raise the hypothesis that statins may prevent or moderate rickettsial disease in exposed people.
%$ 050 ; 052