Statins limit Rickettsia conorii infection in cells Botelho-Nevers, E. Rolain, J. M. Espinosa, L. /Raoult, Didier Statins Prevention Rickettsioses Rickettsia conorii Recent data suggest that statins may have a beneficial effect during sepsis. In this study, we tested the effect of lovastatin and pravastatin on the cellular culture of Rickettsia conorii using a quantitative plaque assay model associated with an original image analysis algorithm. Statins added at the time of infection did not modify plaque formation, whereas pre-incubation with statins for 48 h resulted in a significant 30-68% plaque reduction, depending on the tested compounds and doses. These preliminary findings raise the hypothesis that statins may prevent or moderate rickettsial disease in exposed people. 2008 text https://www.documentation.ird.fr/hor/fdi:010044029 fdi:010044029 Botelho-Nevers E., Rolain J. M., Espinosa L., Raoult Didier. Statins limit Rickettsia conorii infection in cells. 2008, 32 (4), 344-348 EN