@article{fdi:010044029,
  title = {{S}tatins limit {R}ickettsia conorii infection in cells},
  author = {{B}otelho-{N}evers, {E}. and {R}olain, {J}. {M}. and {E}spinosa, {L}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{R}ecent data suggest that statins may have a beneficial effect during sepsis. {I}n this study, we tested the effect of lovastatin and pravastatin on the cellular culture of {R}ickettsia conorii using a quantitative plaque assay model associated with an original image analysis algorithm. {S}tatins added at the time of infection did not modify plaque formation, whereas pre-incubation with statins for 48 h resulted in a significant 30-68% plaque reduction, depending on the tested compounds and doses. {T}hese preliminary findings raise the hypothesis that statins may prevent or moderate rickettsial disease in exposed people.},
  keywords = {{S}tatins ; {P}revention ; {R}ickettsioses ; {R}ickettsia conorii},
  booktitle = {},
  journal = {{I}nternational {J}ournal of {A}ntimicrobial {A}gents},
  volume = {32},
  numero = {4},
  pages = {344--348},
  ISSN = {0924-8579},
  year = {2008},
  DOI = {10.1016/j.ijantimicag.2008.04.027},
  URL = {https://www.documentation.ird.fr/hor/fdi:010044029},
}