%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Kamgno, J.
%A Boussinesq, Michel
%A Labrousse, F.
%A Nkegoum, B.
%A Thylefors, B. I.
%A Mackenzie, C. D.
%T Case report : Encephalopathy after ivermectin treatment in a patient infected with Loa loa and Plasmodium spp
%D 2008
%L fdi:010043757
%G ENG
%J American Journal of Tropical Medicine and Hygiene
%@ 0002-9637
%M CC:0002549433-0006
%N 4
%P 546-551
%U https://www.documentation.ird.fr/hor/fdi:010043757
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-08/010043757.pdf
%V 78
%W Horizon (IRD)
%X Despite over 350 million people being safely treated with ivermectin, there have been rare cases of death post-treatment; these events are most often associated with high Loa loa microfilaremia. This first autopsy description of an encephalopathy case following the administration of ivermectin involves a 45-year-old male who became comatose 3 days after treatment. He slowly deteriorated over 5 weeks and died at 54 days after the anthelminthic treatment, probably as a result of a secondary skin or pulmonary infection exacerbated by malnutrition. The major pre- and post-autopsy findings included the presence of high loads of Loa loa, positivity for Plasmodium, the presence of a longstanding respiratory condition, and vascular pathology in the brain. The central nervous system lesions have similarities with those described in previously reported cases of Loa loa-associated death following diethylcarbamazine treatment.
%$ 052 ; 050