Brutus Laurent auteur aut IRD Watier L. auteur aut IRD Hanitrasoarnampionona V. auteur aut IRD Razanatsoarilala H. auteur aut IRD Cot Michel auteur aut IRD text journalArticle eng text/pdf reformatted digital access A controlled randomized trial of anti-helminthic treatment was undertaken in 1996-1997 in a rural area of Madagascar where populations were simultaneously infected with Ascaris lumbricoides, Plasmodiurn falciparum, and Schistosoma mansoni. Levamisole was administered bimonthly to 107 subjects, whereas 105 were controls. Levamisole was highly effective in reducing Ascaris egg loads in the treated group (P < 10(-3) at all visits), whereas it had no effect on schistosomiasis. Subjects 5-14 years of age, treated with levamisole, had a significant increase of their P. falciparum densities compared with controls (P = 0.003). There was no effect of the treatment on children 6 months to 4 years of age, nor on adults > 15 years of age. This study confirms the results of a randomized trial, which showed a negative interaction in those > 5 years of age between Ascaris and malaria parasite density in another Malagasy population, submitted to a higher malaria transmission. specialized 052 77 6 1091-1095 2007 0002-9637 https://www.documentation.ird.fr/hor/fdi:010043753 0002-9637 [F B010043753] https://www.documentation.ird.fr/hor/fdi:010043753 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers19-08/010043753.pdf IRD - Base Horizon / Pleins textes 2008-05-30 2019-09-19 fdi:010043753 fre