@article{fdi:010043748,
  title = {{S}ex-specific responses to zinc supplementation in {N}ouna, {B}urkina {F}aso},
  author = {{G}arenne, {M}ichel and {B}echer, {H}. and {Y}e, {Y}. and {K}ouyate, {B}. and {M}ueller, {O}.},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjectives: {T}o study the different responses by sex to zinc supplementation among young children. {S}tudy {C}hildren and {M}ethods: {D}ouble-blind randomized controlled trial of zinc supplementation in 686 children aged 6-30 months, conducted in {N}ouna, a rural area of {B}urkina {F}aso. {C}hildren received either a 12.5-mg zinc sulfate tablet or a placebo every day for about 6 months. {O}utcomes were morbidity, nutritional status, and mortality. {R}esults: {R}esults revealed significant differences between boys and girls in their responses to zinc supplementation. {B}oys who received the zinc preparation had fewer days with diarrhea than did control boys ({RR} = 0.88, {P} = 0.05), especially less nonfebrile diarrhea ({RR} = 0.72, {P} < 0.001) and less dysentery ({RR} = 0.65, {P} = 0.05), but more ear infections ({RR} = 4.00, {P} < 0.001). {B}y contrast, girls who received the zinc supplement had the same prevalence of diarrhea as did control girls, but more dysentery ({RR} = 3.70, {P} < 0.001), fewer ear infections ({RR} = 0.39, {P} < 0.001), and fewer eye infections ({RR} = 0.41, {P} < 0.001). {T}he effect of supplementation on nutritional status was not detectable in boys, but girls who received supplementation experienced a faster growth velocity in height than did control girls ({P} = 0.004) and a faster growth velocity for weight and height if they were wasted and not stunted at baseline ({P} = 0.003). {C}onclusions: {Z}inc supplementation had positive, nil, or negative effects depending on pathological condition, and the effects were different for boys than for girls.},
  keywords = {zinc supplementation ; morbidity ; diarrhea ; dysentery ; malaria ; nutritiona ; status ; immunity ; sex differences ; {B}urkina {F}aso},
  booktitle = {},
  journal = {{J}ournal of {P}ediatric {G}astroenterology and {N}utrition},
  volume = {44},
  numero = {5},
  pages = {619--628},
  ISSN = {0277-2116},
  year = {2007},
  DOI = {10.1097/{MPG}.0b013e31802c695e},
  URL = {https://www.documentation.ird.fr/hor/fdi:010043748},
}