@article{fdi:010043234, title = {{I}ncreased {P}lasmodium falciparum gametocyte production in mixed infections with {P}. malariae}, author = {{B}ousema, {J}. {T}. and {D}rakeley, {C}. {J}. and {M}ens, {P}. {F}. and {A}rens, {T}. and {H}ouben, {R}. and {O}mar, {S}. {A}. and {G}ouagna, {L}ouis-{C}l{\'e}ment and {S}challig, {H}. and {S}auerwein, {R}. {W}.}, editor = {}, language = {{ENG}}, abstract = {{P}lasmodium falciparum and {P}. malariae occur endemically in many parts of {A}frica. {O}bservations from malariotherapy patients suggest that co-infection with {P}. malariae may increase {P}. falciparum gametocyte production. {W}e determined {P}. falciparum gametocyte prevalence and density by quantitative nucleic acid sequence-based amplification ({QT}-{NASBA}) after antimalarial treatment of {K}enyan children with either {P}. falciparum mono-infection or {P}. falciparum and {P}. malariae mixed infection. {I}n addition, we analyzed the relationship between mixed species infections and microscopic {P}. falciparum gametocyte prevalence in three datasets from previously published studies. {I}n {K}enyan children, {QT}-{NASBA} gametocyte density was increased in mixed species infections ({P} = 0.03). {W}e also observed higher microscopic prevalences of {P}. falciparum gametocytes in mixed species infections in studies from {T}anzania and {K}enya (odds ratio = 2.15, 95% confidence interval = 0.99-4.65 and 2.39, 1.58-3.63) but not in a study from {N}igeria. {T}hese data suggest that co-infection with {P}. malariae is correlated with increased {P}. falciparum gametocytemia.}, keywords = {}, booktitle = {}, journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene}, volume = {78}, numero = {3}, pages = {442--448}, ISSN = {0002-9637}, year = {2008}, URL = {https://www.documentation.ird.fr/hor/fdi:010043234}, }