@article{fdi:010042973,
  title = {{D}ifferential gene expression in benznidazole-resistant {T}rypanosoma cruzi parasites},
  author = {{V}illarreal, {D}. and {N}irde, {P}. and {H}ide, {M}allorie and {B}arnab{\'e}, {C}hristian and {T}ibayrenc, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e analyzed the differential gene expression among representative {T}rypanosoma cruzi stocks in relation to benznidazole exposures using a random differentially expressed sequences ({RADES}) technique. {S}tudies were carried out with drug pressure both at the natural susceptibility level of the wild-type parasite (50% inhibitory concentration for the wild type) and at different resistance levels. {T}he pattern of differential gene expression performed with resistant stocks was compared to the population structure of this parasite, established by random amplified polymorphic {DNA} analysis and multilocus enzyme electrophoresis. {A} {RADES} band polymorphism was observed, and over- or underexpression was linked to the resistance level of the stock. {T}he analysis of {RADES} bands suggested that different products may be involved in benznidazole resistance mechanisms. {N}o significant association was found between phylogenetic clustering and benznidazole susceptibility. {B}enznidazole resistance may involve several mechanisms, depending on the level of drug exposure.},
  keywords = {},
  booktitle = {},
  journal = {{A}ntimicrobial {A}gents and {C}hemotherapy},
  volume = {49},
  numero = {7},
  pages = {2701--2709},
  ISSN = {0066-4804},
  year = {2005},
  DOI = {10.1128/{AAC}.49.7.2701-2709.2005},
  URL = {https://www.documentation.ird.fr/hor/fdi:010042973},
}