@article{fdi:010042780,
  title = {{T}owards a vaccine against pregnancy-associated malaria},
  author = {{T}uikue {N}dam, {N}icaise and {D}eloron, {P}hilippe},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he consequences of pregnancy-associated malaria on pregnant women (anaemia), their babies (birth weight reduction), and infants (increased morbidity and mortality) are well documented. {F}ield observations during the lost decade have underlined the key role of the interactions between {P}. falciparum variable surface antigens expressed on infected erythrocytes and a novel receptor: chondroitin sulfate {A} ({CSA}) for the placental sequestration of infected erythrocytes. {I}dentification of a distinct {P}. falciparum erythrocyte membrane protein 1 ({P}f{EMP}1) variant, {VAR}2{CSA}, as the dominant variant surface antigen and as a clinically important target for protective immune response to pregnancy-associated malaria has rased hope for developing a new preventive strategy based on inducing these immune responses by vaccination. {H}owever, despite particular structure and interclonal conservation of {VAR}2{CSA} among other {P}f{EMP}1, significant challenges still exist concerning the development of a {VAR}2{CSA}-based vaccine with profound efficacy.},
  keywords = {{P} falciparum ; {M}alaria ; {P}regnancy ; {V}accine},
  booktitle = {},
  journal = {{P}arasite},
  volume = {15},
  numero = {3},
  pages = {515--521},
  ISSN = {1252-607{X}},
  year = {2008},
  URL = {https://www.documentation.ird.fr/hor/fdi:010042780},
}