@article{fdi:010042725,
  title = {{A}dherence and effectiveness of drug combination in curative treatment among children suffering uncomplicated malaria in rural {S}enegal},
  author = {{S}ouares, {A}ur{\'e}lia and {L}alou, {R}ichard and {S}ene, {I}. and {S}ow, {D}. and {L}e {H}esran, {J}ean-{Y}ves},
  editor = {},
  language = {{ENG}},
  abstract = {{I}ncreased {P}lasmodium falciparum resistance to chloroquine has prompted national malaria programs to develop new policies in several {A}frican countries. {L}ess than a year after the introduction of amodiaquine/sulfadoxine-pyrimethamine ({AQ}/{SP}) as first-line treatment in {S}enegal, we examined adherence rates to therapy and its efficacy among children. {T}he study was conducted in five dispensaries in rural {S}enegal. {C}hildren aged 2-10 years with a presumptive diagnosis of malaria were prescribed {AQ}/{SP}. {T}hick blood film analyses were carried out on days 0, 3, 7, 14 and 28. {B}lood and urine samples were collected on day 3 for drug {L}evel measurements. {T}he principal caregivers were questioned on treatment adherence. {A}mong the 289 recruited children, 144 had a parasitemia >2500/mu l. {T}he results demonstrated markedly good efficacy for the treatment, as no detectable parasitemia was observed on day 28 for 97.9% of the children. {H}owever, we noticed that 35.3% of children did not comply with the recommended doses and 62.3% did not exactly adhere to the drug schedule. {D}espite the good efficacy of the drugs, adherence to the therapeutic scheme was poor. {S}trategies to promote patient adherence would improve drug performance and thus might help to prevent the rapid emergence of drug resistance.},
  keywords = {{M}alaria ; {D}rug combination therapy ; {A}dherence ; {T}reatment outcome ; {C}hild ; {S}enegal},
  booktitle = {},
  journal = {{T}ransactions of the {R}oyal {S}ociety of {T}ropical {M}edicine and {H}ygiene},
  volume = {102},
  numero = {8},
  pages = {751--758},
  ISSN = {0035-9203},
  year = {2008},
  DOI = {10.1016/j.trstmh.2008.05.016},
  URL = {https://www.documentation.ird.fr/hor/fdi:010042725},
}