@article{fdi:010042706,
  title = {{L}andscape refuges delay resistance of the {E}uropean corn borer to {B}t-maize : a demo-genetic dynamic model},
  author = {{T}yutyunov, {Y}. and {Z}hadanovskaya, {E}. and {B}ourguet, {D}enis and {A}rditi, {R}.},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e constructed a reaction-diffusion model of the development of resistance to transgenic insecticidal {B}t crops in pest populations. {K}ostitzin's demo-genetic model describes local interactions between three competing pest genotypes with alleles conferring resistance or susceptibility to transgenic plants, the spatial spread of insects being modelled by diffusion. {T}his new approach makes it possible to combine a spatial demographic model of population dynamics with classical genetic theory. {W}e used this model to examine the effects of pest dispersal and of the size and shape of the refuge on the efficiency of the "high-dose/refuge" strategy, which was designed to prevent the development of resistance in populations of insect pests, such as the {E}uropean corn borer, {O}strinia nubilalis {H}ubner ({L}epidoptera, {C}rambidae). {W}e found that, with realistic combinations of refuge size and pest dispersal, the development of resistance could be considerably delayed. {W}ith a small to medium-sized farming area, contiguous refuge plots are more efficient than a larger number of smaller refuge patches. {W}e also show that the formal coupling of classical {F}isher-{H}aldane-{W}right population genetics equations with diffusion terms inaccurately describes the development of resistance in a spatially heterogeneous pest population, notably overestimating the speed with which {B}t resistance is selected in populations of pests targeted by {B}t crops.},
  keywords = {{B}acillus thuringiensis ; {G}enetically modified maize ; {S}patial spread of bt-resistance gene ; {S}patio-temporal dynamics ; {R}esistance management},
  booktitle = {},
  journal = {{T}heoretical {P}opulation {B}iology},
  volume = {74},
  numero = {1},
  pages = {138--146},
  ISSN = {0040-5809},
  year = {2008},
  DOI = {10.1016/j.tpb.2008.05.005},
  URL = {https://www.documentation.ird.fr/hor/fdi:010042706},
}