%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Brinkhof, M. W. G.
%A Dabis, F.
%A Myer, L.
%A Bangsberg, D. R.
%A Boulle, A.
%A Nash, D.
%A Schechter, M.
%A Laurent, Christian
%A Keiser, O.
%A May, M.
%A Sprinz, E.
%A Egger, M.
%A Anglaret, X.
%T Early loss of HIV-infected patients on potent antiretroviral therapy programmes in lower-income countries
%D 2008
%L fdi:010042671
%G ENG
%J Bulletin of the World Health Organization
%@ 0042-9686
%M ISI:000257421900014
%N 7
%P 559-567
%R 10.2471/BLT.07.044248
%U https://www.documentation.ird.fr/hor/fdi:010042671
%> https://www.documentation.ird.fr/intranet/publi/2008/08/010042671.pdf
%V 86
%W Horizon (IRD)
%X Objective To analyse the early loss of patients to antiretroviral therapy (ART) programmes in resource-limited settings. Methods Using data on 5491 adult patients starting ART (median age 35 years, 46% female) in 15 treatment programmes in Africa, Asia and South America with >= 12 months of follow-up, we investigated risk factors for no follow-up after treatment initiation, and loss to follow-up or death in the first 6 months. Findings Overall, 211 patients (3.8%) had no follow-up, 880 (16.0%) were lost to follow-up and 141 (2.6%) were known to have died in the first 6 months. The probability of no follow-up was higher in 2003-2004 than in 2000 or earlier (odds ratio, OR: 5.06; 95% confidence interval, CI: 1.28-20.0), as was loss to follow-up (hazard ratio, HR: 7.62; 95% CI: 4.55-12.8) but not recorded death (HR: 1.02; 95% CI: 0.44-2.36). Compared with a baseline CD4-cell count >= 50 cells/mu l, a count < 25 cells/mu l was associated with a higher probability of no follow-up (OR: 2,49; 95% CI: 1.43-4.33), loss to follow-up (HR: 1.48; 95% CI: 1.23-1.77) and death (HR: 3.34; 95% CI: 2.10-5.30). Compared to free treatment, fee-for-service programmes were associated with a higher probability of no follow-up (OR: 3.71; 95% CI: 0.97-16.05) and higher mortality (HR: 4.64; 95% CI: 1.11-19.41). Conclusion Early patient losses were increasingly common when programmes were scaled up and were associated with a fee for service and advanced immunodeficiency at baseline. Measures to maximize ART programme retention are required in resource-poor countries.
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