@article{fdi:010042671,
  title = {{E}arly loss of {HIV}-infected patients on potent antiretroviral therapy programmes in lower-income countries},
  author = {{B}rinkhof, {M}. {W}. {G}. and {D}abis, {F}. and {M}yer, {L}. and {B}angsberg, {D}. {R}. and {B}oulle, {A}. and {N}ash, {D}. and {S}chechter, {M}. and {L}aurent, {C}hristian and {K}eiser, {O}. and {M}ay, {M}. and {S}prinz, {E}. and {E}gger, {M}. and {A}nglaret, {X}.},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjective {T}o analyse the early loss of patients to antiretroviral therapy ({ART}) programmes in resource-limited settings. {M}ethods {U}sing data on 5491 adult patients starting {ART} (median age 35 years, 46% female) in 15 treatment programmes in {A}frica, {A}sia and {S}outh {A}merica with >= 12 months of follow-up, we investigated risk factors for no follow-up after treatment initiation, and loss to follow-up or death in the first 6 months. {F}indings {O}verall, 211 patients (3.8%) had no follow-up, 880 (16.0%) were lost to follow-up and 141 (2.6%) were known to have died in the first 6 months. {T}he probability of no follow-up was higher in 2003-2004 than in 2000 or earlier (odds ratio, {OR}: 5.06; 95% confidence interval, {CI}: 1.28-20.0), as was loss to follow-up (hazard ratio, {HR}: 7.62; 95% {CI}: 4.55-12.8) but not recorded death ({HR}: 1.02; 95% {CI}: 0.44-2.36). {C}ompared with a baseline {CD}4-cell count >= 50 cells/mu l, a count < 25 cells/mu l was associated with a higher probability of no follow-up ({OR}: 2,49; 95% {CI}: 1.43-4.33), loss to follow-up ({HR}: 1.48; 95% {CI}: 1.23-1.77) and death ({HR}: 3.34; 95% {CI}: 2.10-5.30). {C}ompared to free treatment, fee-for-service programmes were associated with a higher probability of no follow-up ({OR}: 3.71; 95% {CI}: 0.97-16.05) and higher mortality ({HR}: 4.64; 95% {CI}: 1.11-19.41). {C}onclusion {E}arly patient losses were increasingly common when programmes were scaled up and were associated with a fee for service and advanced immunodeficiency at baseline. {M}easures to maximize {ART} programme retention are required in resource-poor countries.},
  keywords = {},
  booktitle = {},
  journal = {{B}ulletin of the {W}orld {H}ealth {O}rganization},
  volume = {86},
  numero = {7},
  pages = {559--567},
  ISSN = {0042-9686},
  year = {2008},
  DOI = {10.2471/{BLT}.07.044248},
  URL = {https://www.documentation.ird.fr/hor/fdi:010042671},
}