@article{fdi:010042637,
  title = {{T}he hyperthermophilic anaerobe {T}hermotoga {M}aritima is able to cope with limited amount of oxygen : insights into its defence strategies},
  author = {{L}e {F}ourn, {C}. and {F}ardeau, {M}arie-{L}aure and {O}llivier, {B}ernard and {L}ojou, {E}. and {D}olla, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}hermotoga maritima, an anaerobic hyperthermophilic bacterium, was found able to grow in the presence of low concentrations of oxygen of up to 0.5% (v/v). {D}ifferential proteomics and transcripts analysis by q{RT}-{PCR} were used to identify the defence strategies used by {T}. maritima to protect itself against oxygen. {A} flavoprotein, homologous to rubredoxin oxygen oxidoreductase was found to be overproduced when cells were cultured in oxidative conditions. {T}he recombinant protein, produced in {E}scherichia coli, exhibited an oxygen reductase activity, which could account for the observed decrease in oxygen concentration during growth. {T}he gene encoding this oxygen reductase belongs to a multicistronic unit that includes genes encoding proteins involved in exopolysaccharide biosynthesis, which may be related to a biofilm formation induced by the presence of oxygen. {E}nzymes involved in reactive oxygen species detoxification, iron-sulfur centre synthesis/repair and the cysteine biosynthesis pathway were also overproduced. {A}ll these enzymatic systems together contribute to the defence strategy of {T}. maritima against oxygen. {B}ecause of the position of {T}. maritima in deep branches of the phylogenetic tree, we suggest that these strategies can be considered as ancestral mechanisms first developed by anaerobic microorganisms on the early {E}arth to protect themselves against primary abiotic or biotic oxygen production.},
  keywords = {},
  booktitle = {},
  journal = {{E}nvironmental {M}icrobiology},
  volume = {10},
  numero = {7},
  pages = {1877--1887},
  ISSN = {1462-2912},
  year = {2008},
  DOI = {10.1111/j.1462-2920.2008.01610.x},
  URL = {https://www.documentation.ird.fr/hor/fdi:010042637},
}