@article{fdi:010042634,
  title = {{M}olecular tracing of sexual {HIV} type 1 transmission in the southwest border of {C}hina},
  author = {{B}ao, {L}. {L}. and {V}idal, {N}icole and {F}ang, {H}. and {D}eng, {W}. and {C}hen, {S}. and {G}uo, {W}. {Z}. and {Q}in, {C}. and {P}eeters, {M}artine and {D}elaporte, {E}ric and {A}ndrieu, {J}. {M}. and {L}u, {W}ei},
  editor = {},
  language = {{ENG}},
  abstract = {{S}ince the first outbreak of {HIV}-1 was reported in heroin users in {C}hina in 1989, {HIV}-1 has spread steadily among injection drug users, leading to an exponential growth of nationwide outbreaks from 1998 to 2004. {H}owever, the impact of sexual transmission on outbreaks of {HIV} in {C}hina's general population is still unclear. {T}hrough a governmental {HIV}/{AIDS} surveillance program, an {HIV} serological study was conducted in volunteers between 1996 and 2005 in {X}ishuangbanna {D}ai {A}utonomous {P}refecture of {Y}unnan province. {W}e performed the transmission reconstruction by molecular epidemiological tracing in a subset of the {HIV}-1-seropositive individuals diagnosed during this survey. {N}eighbor joining and maximum likelihood trees based on the {HIV}-1 pol and env genes were implemented to provide information on putative epidemiological links, which were then confirmed by contact tracing. {O}f 25,390 volunteers, 501 (2%) accumulated cases of {HIV}-1 infection (21.1% in needle-sharing drug users, 77.3% in heterosexual adults, 0.4% in homosexual adults, and 1.2% in children born from infected mothers) were diagnosed. {A}mong 44 heterosexually infected and antiretroviral-naive local-traceable individuals (27 infected with {HIV}-1 subtype {CRF}01_{AE}, 15 with {CRF}08_{BC}, 1 with {G}, and 1 with a new {B}/{C} recombinant), 18 (40.9%) were coclustered into 8 transmission chains with an average size of 2.25 infections per chain. {P}hylogenetic and epidemiological linkages confirmed eight heterosexual transmission events. {T}his is the first report providing molecular epidemiological evidence of heterosexual transmission of {HIV}-1 in {C}hina's general population. {T}he reconstruction of transmission of current {HIV}-1 outbreaks by molecular epidemiological tracing is instrumental in identifying sources of the epidemic and in defining prevention strategies.},
  keywords = {},
  booktitle = {},
  journal = {{AIDS} {R}esearch and {H}uman {R}etroviruses},
  volume = {24},
  numero = {5},
  pages = {733--742},
  ISSN = {0889-2229},
  year = {2008},
  DOI = {10.1089/aid.2007.0269},
  URL = {https://www.documentation.ird.fr/hor/fdi:010042634},
}