@article{fdi:010042621,
  title = {{H}ost genetics in {A}frican trypanosomiasis},
  author = {{C}ourtin, {D}. and {B}erthier, {D}. and {T}hevenon, {S}. and {D}ayo, {G}. {K}. and {G}arcia, {A}ndr{\'e} and {B}ucheton, {B}runo},
  editor = {},
  language = {{ENG}},
  abstract = {{I}n {A}frica, the protozoan parasite of the genus {T}rypanosoma causes animal ({AAT}) and human {A}frican trypanosomiasis ({HAT}). {T}hese diseases are responsible for considerable mortality and economic losses, and until now the drugs commonly used have often been very toxic and expensive, with no vaccine available. {A} range of clinical presentations, from chronic to acute symptoms, is observed in both {AAT} and {HAT}. {H}ost, parasite, and environmental factors are likely to be involved in this clinical variability. {I}n {AAT}, some {W}est {A}frican cattle ({N}'{D}ama, {B}os taurus) have the ability to better control the disease development (and therefore to remain productive) than other taurine breeds ({Z}ebu, {B}os indicus). {T}his phenomenon is called trypanotolerance and seems to have major genetic components. {I}n humans, tolerance/resistance to the disease is suspected, however, this needs confirmation. {T}his review focuses on recent advances made in the field of host genetics in {A}frican trypanosomiasis in animals (mouse and bovine) and humans. {T}he perspectives for the development of new control strategies and their applications as well as a better understanding of the physiopathology of the disease are discussed.},
  keywords = {trypanotolerance ; genetic susceptibility ; {T}rypanosoma brucei ; human {A}frican trypanosomiasis ; animal {A}frican trypanosomiasis ; sleeping sickness},
  booktitle = {},
  journal = {{I}nfection {G}enetics and {E}volution},
  volume = {8},
  numero = {3},
  pages = {229--238},
  ISSN = {1567-1348},
  year = {2008},
  DOI = {10.1016/j.meegid.2008.02.007},
  URL = {https://www.documentation.ird.fr/hor/fdi:010042621},
}