@article{fdi:010042596,
  title = {{C}osts and benefits of multiple resistance to insecticides for {C}ulex quinquefasciatus mosquitoes},
  author = {{B}erticat, {C}. and {B}onnet, {J}ulien and {D}uchon, {S}t{\'e}phane and {A}gnew, {P}hilip and {W}eill, {M}. and {C}orbel, {V}incent},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}he evolutionary dynamics of xenobiotic resistance depends on how resistance mutations influence the fitness of their bearers, both in the presence and absence of xenobiotic selection pressure. {I}n cases of multiple resistance, these dynamics will also depend on how individual resistance mutations interact with one another, and on the xenobiotics applied against them. {W}e compared {C}ulex quinquefasciatus mosquitoes harbouring two resistance alleles ace-{I}-{R} and {K}dr({R}) (conferring resistance to carbamate and pyrethroid insecticides, respectively) to mosquitoes bearing only one of the alleles, or neither allele. {C}omparisons were made in environments where both, only one, or neither type of insecticide was present. {R}esults: {E}ach resistance allele was associated with fitness costs ( survival to adulthood) in an insecticide-free environment, with the costs of ace-{I}-{R} being greater than for {K}dr({R}). {H}owever, there was a notable interaction in that the costs of harbouring both alleles were significantly less than for harbouring ace-{I}-{R} alone. {T}he two insecticides combined in an additive, synergistic and antagonistic manner depending on a mosquito's resistance status, but were not predictable based on the presence/absence of either, or both mutations. {C}onclusion: {I}nsecticide resistance mutations interacted to positively or negatively influence a mosquito's fitness, both in the presence or absence of insecticides. {I}n particular, the presence of the {K}dr({R}) mutation compensated for the costs of the ace-{I}-{R} mutation in an insecticide-free environment, suggesting the strength of selection in untreated areas would be less against mosquitoes resistant to both insecticides than for those resistant to carbamates alone. {A}dditional interactions suggest the dynamics of resistance will be difficult to predict in populations where multiple resistance mutations are present or that are subject to treatment by different xenobiotics.},
  keywords = {},
  booktitle = {},
  journal = {{B}mc {E}volutionary {B}iology},
  volume = {8},
  numero = {},
  pages = {{NIL}_1--{NIL}_9 ; art. no. 104},
  ISSN = {1471-2148},
  year = {2008},
  DOI = {10.1186/1471-2148-8-104},
  URL = {https://www.documentation.ird.fr/hor/fdi:010042596},
}