@article{fdi:010042548,
  title = {{T}he {VIZIER} project : {P}reparedness against pathogenic {RNA} viruses},
  author = {{C}outard, {B}. and {G}orbalenya, {A}. {E}. and {S}nijder, {E}. {J}. and {L}eontovich, {A}. {M}. and {P}oupon, {A}. and de {L}amballerie, {X}avier and {C}harrel, {R}. and {G}ould, {E}. {A}. and {G}unther, {S}. and {N}order, {H}. and {K}lempa, {B}. and {B}ourhy, {H}. and {R}ohayem, {J}. and {L}' hermite, {E}. and {N}ordlund, {P}. and {S}tuart, {D}. {I}. and {O}wens, {R}. {J}. and {G}rimes, {J}. {M}. and {T}ucker, {P}. {A}. and {B}olognesi, {M}. and {M}attevi, {A}. and {C}oll, {M}. and {J}ones, {T}. {A}. and {A}qvist, {J}. and {U}nge, {T}. and {H}ilgenfeld, {R}. and {B}ricogne, {G}. and {N}eyts, {J}. and {L}a {C}olla, {P}. and {P}uerstinger, {G}. and {G}onzalez, {J}ean-{P}aul and {L}eroy, {E}ric and {C}ambillau, {C}. and {R}omette, {J}. {L}. and {C}anard, {B}.},
  editor = {},
  language = {{ENG}},
  abstract = {{L}ife-threatening {RNA} viruses emerge regularly, and often in an unpredictable manner. {Y}et, the very few drugs available against known {RNA} viruses have sometimes required decades of research for development. {C}an we generate preparedness for outbreaks of the, as yet, unknown viruses? {T}he {VIZIER} ({VI}ral en{Z}ymes {I}nvolv{E}d in {R}eplication) (http://www.vizier-europe.org/) project has been set-up to develop the scientific foundations for countering this challenge to society. {VIZIER} studies the most conserved viral enzymes (that of the replication machinery, or replicases) that constitute attractive targets for drug-design. {T}he aim of {VIZIER} is to determine as many replicase crystal structures as possible from a carefully selected list of viruses in order to comprehensively cover the diversity of the {RNA} virus universe, and generate critical knowledge that could be efficiently utilized to jump-start research on any emerging {RNA} virus. {VIZIER} is a multidisciplinary project involving (i) bioinformatics to define functional domains, (ii) viral genomics to increase the number of characterized viral genomes and prepare defined targets, (iii) proteomics to express, purify, and characterize targets, (iv) structural biology to solve their crystal structures, and (v) pre-lead discovery to propose active scaffolds of antiviral molecules.},
  keywords = {{RNA} virus ; genomics ; crystal structure ; replicase ; antivirals ; drug design},
  booktitle = {},
  journal = {{A}ntiviral {R}esearch},
  volume = {78},
  numero = {1},
  pages = {37--46},
  ISSN = {0166-3542},
  year = {2008},
  DOI = {10.1016/j.antiviral.2007.10.013},
  URL = {https://www.documentation.ird.fr/hor/fdi:010042548},
}