Holzmuller P. auteur aut IRD Biron D. G. auteur aut IRD Courtois P. auteur aut IRD Koffi M. auteur aut IRD Bras Goncalves Rachel auteur aut IRD Daulouede S. auteur aut IRD Solano Philippe auteur aut IRD Cuny Gérard auteur aut IRD Vincendeau P. auteur aut IRD Jamonneau Vincent auteur aut IRD text journalArticle eng text/pdf born digital access Human African trypanosomiasis is characterised by an important clinical diversity. Although Trypanosoma brucei gambiense field stocks isolated from patients in the same focus did not exhibit apparent genetic variability, they showed marked differences in terms of virulence (capacity to multiply inside a host) and pathogenicity (ability of producing mortality) in experimental murine infections. Two strains exhibiting opposite pathogenic and virulence properties in mouse were further investigated through their host-parasite interactions. In vitro, parasite bloodstream forms or soluble factors (or secretome) from both strains induced macrophage arginase as a function of their virulence. Arginase expression, a hallmark of macrophage alternative activation pathway, favours trypanosome bloodstream forms development. Moreover, a comparative proteomic study of the trypanosome stocks' secretomes evidenced both a differential expression of common molecules and the existence of stock specific molecules. This highlighted the potential involvement of the differential expression of the same genome in the diverse infectious properties of trypanosomes. specialized trypanosoma brucei gambiense virulence pathogenicity parasite soluble factors immunomodulation proteomics 052 10 1 79-86 2008 1286-4579 https://www.documentation.ird.fr/hor/fdi:010042524 10.1016/j.micinf.2007.10.008 1286-4579 [F B010042524] https://www.documentation.ird.fr/hor/fdi:010042524 https://www.documentation.ird.fr/intranet/publi/2008/04/010042524.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2008-05-06 2017-08-23 fdi:010042524 fre