@article{fdi:010042524,
  title = {{V}irulence and pathogenicity patterns of {T}rypanosoma brucei gambiense field isolates in experimentally infected mouse : differences in host immune response modulation by secretome and proteomics},
  author = {{H}olzmuller, {P}. and {B}iron, {D}. {G}. and {C}ourtois, {P}. and {K}offi, {M}. and {B}ras {G}oncalves, {R}achel and {D}aulouede, {S}. and {S}olano, {P}hilippe and {C}uny, {G}{\'e}rard and {V}incendeau, {P}. and {J}amonneau, {V}incent},
  editor = {},
  language = {{ENG}},
  abstract = {{H}uman {A}frican trypanosomiasis is characterised by an important clinical diversity. {A}lthough {T}rypanosoma brucei gambiense field stocks isolated from patients in the same focus did not exhibit apparent genetic variability, they showed marked differences in terms of virulence (capacity to multiply inside a host) and pathogenicity (ability of producing mortality) in experimental murine infections. {T}wo strains exhibiting opposite pathogenic and virulence properties in mouse were further investigated through their host-parasite interactions. {I}n vitro, parasite bloodstream forms or soluble factors (or secretome) from both strains induced macrophage arginase as a function of their virulence. {A}rginase expression, a hallmark of macrophage alternative activation pathway, favours trypanosome bloodstream forms development. {M}oreover, a comparative proteomic study of the trypanosome stocks' secretomes evidenced both a differential expression of common molecules and the existence of stock specific molecules. {T}his highlighted the potential involvement of the differential expression of the same genome in the diverse infectious properties of trypanosomes.},
  keywords = {trypanosoma brucei gambiense ; virulence ; pathogenicity ; parasite soluble factors ; immunomodulation ; proteomics},
  booktitle = {},
  journal = {{M}icrobes and {I}nfection},
  volume = {10},
  numero = {1},
  pages = {79--86},
  ISSN = {1286-4579},
  year = {2008},
  DOI = {10.1016/j.micinf.2007.10.008},
  URL = {https://www.documentation.ird.fr/hor/fdi:010042524},
}