Hide Mallorie auteur aut IRD Banuls Anne-Laure auteur aut IRD text journalArticle eng text/pdf born digital access In leishmaniasis, cysteine protease b (cpb) multicopy genes have been extensively studied because of their implication in host-parasite interactions. In the Leishmania donovani complex, responsible for visceral. leishmaniasis, a set of interesting polymorphisms has been revealed, such as copy sequence or expression according to the parasite's life stage. The single nucleotide polymorphisms observed among these copies could be related to clinical characteristics such as dermotropic versus viscerotropic status. CPB COOH-terminal extension (CTE) is mainly responsible for genetic variability among the copies and appears highly immunogenic. These results suggest that further study of the role of CPBs, especially CTE in clinical outcome, is warranted. specialized 052 102 2 105-106 2008 0035-9203 https://www.documentation.ird.fr/hor/fdi:010042489 10.1016/j.trstmh.2007.09.013 0035-9203 [F B010042489] https://www.documentation.ird.fr/hor/fdi:010042489 https://www.documentation.ird.fr/intranet/publi/2008/03/010042489.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2008-03-31 2017-08-23 fdi:010042489 fre