@article{fdi:010042489, title = {{P}olymorphisms of cpb multicopy genes in the {L}eishmania ({L}eishmania) donovani complex}, author = {{H}ide, {M}allorie and {B}anuls, {A}nne-{L}aure}, editor = {}, language = {{ENG}}, abstract = {{I}n leishmaniasis, cysteine protease b (cpb) multicopy genes have been extensively studied because of their implication in host-parasite interactions. {I}n the {L}eishmania donovani complex, responsible for visceral. leishmaniasis, a set of interesting polymorphisms has been revealed, such as copy sequence or expression according to the parasite's life stage. {T}he single nucleotide polymorphisms observed among these copies could be related to clinical characteristics such as dermotropic versus viscerotropic status. {CPB} {COOH}-terminal extension ({CTE}) is mainly responsible for genetic variability among the copies and appears highly immunogenic. {T}hese results suggest that further study of the role of {CPB}s, especially {CTE} in clinical outcome, is warranted.}, keywords = {}, booktitle = {}, journal = {{T}ransactions of the {R}oyal {S}ociety of {T}ropical {M}edicine and {H}ygiene}, volume = {102}, numero = {2}, pages = {105--106}, ISSN = {0035-9203}, year = {2008}, DOI = {10.1016/j.trstmh.2007.09.013}, URL = {https://www.documentation.ird.fr/hor/fdi:010042489}, }