@article{fdi:010041532,
  title = {{D}ifferential infectivity and immunopathology in murine experimental infections by two natural clones belonging to the {T}rypanosoma cruzi {I} lineage},
  author = {{G}arzon, {E}dwin and {G}enna, {F}. and {B}osseno, {M}arie-{F}rance and {S}imony {L}a {F}ontaine, {J}. and {R}adal, {M}. and {S}{\'e}r{\'e}no, {D}enis and {M}athieu {D}aud{\'e}, {F}ran{\c{c}}oise and {O}uaissi, {A}li and {B}reni{\`e}re, {S}imone {F}r{\'e}d{\'e}rique},
  editor = {},
  language = {{ENG}},
  abstract = {{I}mmunopathology of {C}hagas' disease in {B}alb/c mice infected with 2 {T}rypanosoma cruzi clones, belonging to the {T}. cruzi {I} lineage and presenting different in vitro virulence ({P}/209 ell > {SO}34 c14) was compared. {I}n the acute phase, evading mechanisms such as parasite-induced lymphocyte polyclonal activation and {T} cell immunosuppression were higher in mice infected with the clone giving a higher parasitaemia ({P}/209 c11). {A} similar increase of non-specific isotypes was observed in both infections with {I}g{G}2a prevalence. {I}nterestingly, {CD}8+ cell hypercellularity and lymphocyte immunosuppression were observed during the chronic phase (245 days post-infection) in mice infected by the most virulent clone. {I}n the same way, the parasite-specific antibody response was more intense in {P}/209 c11-infected mice over the acute phase. {D}uring the chronic phase this response remarkably dropped down in {SO}34 c14-infected mice exclusively. {F}inally, {P}/209 ell-infected mice presented a more severe inflammation and tissue damage in heart and quadriceps than {SO}34 c14-infected mice. {T}his comparative study showed differences between the two clones: a higher virulence in vivo being clearly associated with a greater ability to induce evasion mechanisms and severe tissue damage.},
  keywords = {{T}rypanosoma cruzi ; genotype ; immunopathology ; virulence ; mouse},
  booktitle = {},
  journal = {{P}arasitology},
  volume = {131},
  numero = {{P}art 1},
  pages = {109--119},
  ISSN = {0031-1820},
  year = {2005},
  DOI = {10.1017/{S}003118200400722{X}},
  URL = {https://www.documentation.ird.fr/hor/fdi:010041532},
}