@article{fdi:010041521,
  title = {{H}igh level of var2csa transcription by {P}lasmodium falciparum isolated from the placenta},
  author = {{T}uikue {N}dam, {N}icaise and {S}alanti, {A}. and {B}ertin, {G}wladys and {D}ahlback, {M}. and {F}ievet, {N}adine and {T}urner, {L}. and {G}aye, {A}. and {T}heander, {T}. and {D}eloron, {P}hilippe},
  editor = {},
  language = {{ENG}},
  abstract = {{P}lasmodium falciparum parasites that bind to chondroitin sulphate {A} ({CSA}) express unique variant surface antigens that are involved in the placental sequestration that precipitates pregnancy-associated malaria ({PAM}). {T}wo var gene subfamilies, var1csa and var2csa, have been associated with {CSA} binding. {W}e show here that placental {P}. falciparum isolates highly transcribed var2csa but not var1csa. var2csa was not transcribed or was only minimally transcribed by parasites isolated from nonpregnant women. {P}lacental parasites that effectively bound to placental chondroitin sulphate proteoglycans transcribed higher levels of var2csa. {I}n pregnant women, levels of var2csa transcription and plasma anti{VAR}2{CSA} immunoglobulin {G} were associated. {T}hese findings support the idea that {VAR}2{CSA} plays a crucial role in {PAM} and strengthen the rationale for the development of {VAR}2{CSA}-based vaccines.},
  keywords = {},
  booktitle = {},
  journal = {{J}ournal of {I}nfectious {D}iseases},
  volume = {192},
  numero = {2},
  pages = {331--335},
  ISSN = {0022-1899},
  year = {2005},
  DOI = {10.1086/430933},
  URL = {https://www.documentation.ird.fr/hor/fdi:010041521},
}