@article{fdi:010041515,
  title = {{S}tage-specific antileishmanial activity of an inhibitor of {SIR}2 histone deacetylase},
  author = {{V}ergnes, {B}aptiste and {V}anhille, {L}aurent and {O}uaissi, {A}li and {S}ereno, {D}enis},
  editor = {},
  language = {{ENG}},
  abstract = {{S}ilent information regulator 2 ({SIR}2) proteins are {NAD}-dependant deacetylases found in organisms ranging from bacteria to human. {I}n eukaryotes, these proteins are involved in many biological processes {I} including transcriptional repression, metabolism, ageing, or apoptosis. {H}ere, we have shown that {S}irtinol, a commercially available inhibitor of {SIR}2 deacetylases, significantly inhibits the in vitro proliferation of {L}eishmania infantum, axenic amastigotes in a dose-dependent manner. {T}his activity is stage specific since sirtinol did not affect the in vitro growth of parasite promastigotes. {G}rowth arrest in amastigotes is associated with genomic {DNA} fragmentation, a process reminiscent of apoptosis. {I}nterestingly parasites carrying extra copies of the {L}m{SIR}2 gene were less susceptible to the sirtinol mediated cell death. {A}ltogether, these results constitute novel evidences that {L}eishmania {SIR}2 proteins play a role in the control of the parasite apoptotic phenomenon. (c) 2005 {E}lsevier {B}.{V}. {A}ll rights reserved.},
  keywords = {organisms ; parasites ; transcriptional repression},
  booktitle = {},
  journal = {{A}cta {T}ropica},
  volume = {94},
  numero = {2},
  pages = {107--115},
  ISSN = {0001-706{X}},
  year = {2005},
  DOI = {10.1016/j.actatropica.2005.03.004},
  URL = {https://www.documentation.ird.fr/hor/fdi:010041515},
}