@article{fdi:010041214,
  title = {{C}haracterization of insensitive acetyleholinesterase (ace-1({R})) in {A}nopheles gambiae ({D}iptera : {C}ulicidae) : {R}esistance levels and dominance},
  author = {{D}jogb{\'e}nou, {L}uc and {W}eill, {M}. and {H}ougard, {J}ean-{M}arc and {R}aymond, {M}. and {A}kogb{\'e}to, {M}. and {C}handre, {F}abrice},
  editor = {},
  language = {{ENG}},
  abstract = {{C}haracterization of insecticide resistance provides data on the evolutionary processes involved in the adaptation of insects to environmental changes. {S}tudying the dominance status and resistance level represents a great interest, in terms of understanding resistance evolution in the field to eventually adapt vector control. {R}esistance and dominance levels conferred by the {G}119{S} mutation of acetylcholinesterase (ace-1({R})) of the mosquito {A}nopheles gambiae s.s. ({D}iptera: {C}ulicidae) were studied for various insecticides belonging to different classes, using strains sharing the same genetic background. {O}ur survey shows that the homozygote resistant strain {A}cer{K}is displayed a very high resistance level to various carbamates (range 3,000- to 5,000-fold) compared with that of various organophosphates (range 12- to 30-fold). {F}urthermore, the dominance status varied between semi-recessivity with fenitrothion and chlorpyrifos methyl insecticides to semidominance with temephos, carbosulfan, and propoxur. {T}hese results indicate that this resistance mechanism could spread rapidly in the field and then compromise the use of organophosphate and carbamate compounds in public health. {T}his study underlines the necessity to monitor the ace-1({R}) mutation in natural populations before planning and implementing malaria control programs based on the use of these insecticides.},
  keywords = {anopheles gambiae ; insecticides ; resistance ; dominance ; acetyleholinesterase},
  booktitle = {},
  journal = {{J}ournal of {M}edical {E}ntomology},
  volume = {44},
  numero = {5},
  pages = {805--810},
  ISSN = {0022-2585},
  year = {2007},
  DOI = {10.1603/0022-2585(2007)44[805:{COIAAI}]2.0.{CO};2},
  URL = {https://www.documentation.ird.fr/hor/fdi:010041214},
}