@article{fdi:010040991,
  title = {{D}ifferential evolution of anti-{VAR}2{CSA}-{I}g{G}3 in primigravidae and multigravidae pregnant women infected by {P}lasmodium falciparum - art. no. 10},
  author = {{G}uitard, {J}uliette and {C}ottrell, {G}illes and {M}oulopo {M}agnouha, {N}ellie and {S}alanti, {A}. and {L}i, {T}engfei and {S}ow, {S}. and {D}eloron, {P}hilippe and {T}uikue {N}dam, {N}icaise},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {P}regnant women develop protective anti-{VSA} {I}g{G}1 and {I}g{G}3 when infected by {P}lasmodium falciparum. {T}he major target of {I}g{G} from serum of infected pregnant women is {VAR}2{CSA}. {M}ethods: {I}n this study, {ELISA} was used to compare the level of {VAR}2{CSA} {DBL}5 epsilon- specific {I}g{G} subclasses at enrolment and at delivery in a cohort of pregnant women in {S}enegal. {A}ll antibody measures were analysed in relation to placental infection according to parity. {R}esults: {T}he results show an interaction between immune response to placental malaria and parity. {A} higher level of anti-{DBL}5 epsilon-{I}g{G}3 at enrolment and a higher increase between enrolment and delivery were found in primigravidae who presented with uninfected placenta at delivery in comparison to those who presented with an infection of the placenta. {H}owever, high antibody level at delivery was associated with the infection of the placenta in multigravidae. {C}onclusion: {T}his high level of {I}g{G}3 in uninfected primigravidae suggests a protective role of these antibodies in this susceptible group, highlighting the importance of {VAR}2{CSA} in general and of some of its variants still to be defined, in the induction of protective immunity to pregnancy malaria.},
  keywords = {},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {7},
  numero = {},
  pages = {{NIL}_8--{NIL}_13},
  ISSN = {1475-2875},
  year = {2008},
  DOI = {10.1186/1475-2875-7-10},
  URL = {https://www.documentation.ird.fr/hor/fdi:010040991},
}