@article{fdi:010040980, title = {{T}racking genome organization in rodents by {Z}oo-{FISH}}, author = {{G}raphodatsky, {A}. {S}. and {Y}ang, {F}. and {D}obigny, {G}authier and {R}omanenko, {S}. {A}. and {B}iltueva, {L}. {S}. and {P}erelman, {P}. {L}. and {B}eklemisheva, {V}. {R}. and {A}lkalaeva, {E}. {Z}. and {S}erdukova, {N}. {A}. and {F}erguson {S}mith, {M}. {A}. and {M}urphy, {W}. {J}. and {R}obinson, {T}. {J}.}, editor = {}, language = {{ENG}}, abstract = {{T}he number of rodent species examined by modern comparative genomic approaches, particularly chromosome painting, is limited. {T}he use of human whole-chromosome painting probes to detect regions of homology in the karyotypes of the rodent index species, the mouse and rat, has been hindered by the highly rearranged nature of their genomes. {I}n contrast, recent studies have demonstrated that non-murid rodents display more conserved genomes, underscoring their suitability for comparative genomic and higher-order systematic studies. {H}ere we provide the first comparative chromosome maps between human and representative rodents of three major rodent lineages {C}astoridae, {P}edetidae and {D}ipodidae. {A} comprehensive analysis of these data and those published for {S}ciuridae show (1) that {C}astoridae, {P}edetidae and {D}ipodidae form a monophyletic group, and (2) that the {E}uropean beaver {C}astor fiber ({C}astoridae) and the birch mouse {S}icista betulina ({D}ipodidae) are sister species to the exclusion of the springhare {P}edetes capensis ({P}edetidae), thus resolving an enduring trifurcation in rodent higher-level systematics. {O}ur results together with published data on the {S}ciuridae allow the formulation of a putative rodent ancestral karyotype (2n=50) that is thought to comprise the following 26 human chromosomal segments and/or segmental associations: {HSA}1pq, 1q/10p, 2pq, 2q, 3a, 3b/19p, 3c/21, 4b, 5, 6, 7a, 7b/16p, 8p/4a/8p, 8q, 9/11, 10q, 12a/22a, 12b/22b, 13, 14/15, 16q/19q, 17, 18, 20, {X} and {Y}. {T}hese findings provide insights into the likely composition of the ancestral rodent karyotype and an improved understanding of placental genome evolution.}, keywords = {}, booktitle = {}, journal = {{C}hromosome {R}esearch}, volume = {16}, numero = {2}, pages = {261--274}, ISSN = {0967-3849}, year = {2008}, DOI = {10.1007/s10577-007-1191-5}, URL = {https://www.documentation.ird.fr/hor/fdi:010040980}, }