@article{fdi:010040978, title = {{P}hylogenomics of the dog and fox family ({C}anidae, {C}arnivora) revealed by chromosome painting}, author = {{G}raphodatsky, {A}. {S}. and {P}erelman, {P}. {L}. and {S}okolovskaya, {N}. {V}. and {B}eklemisheva, {V}. {R}. and {S}erdukova, {N}. {A}. and {D}obigny, {G}authier and {B}rien, {S}. {J}. {O}. and {F}erguson {S}mith, {M}. {A}. and {Y}ang, {F}. {T}.}, editor = {}, language = {{ENG}}, abstract = {{C}anid species (dogs and foxes) have highly rearranged karyotypes and thus represent a challenge for conventional comparative cytogenetic studies. {A}mong them, the domestic dog is one of the best-mapped species in mammals, constituting an ideal reference genome for comparative genomic study. {H}ere we report the results of genome-wide comparative mapping of dog chromosome-specific probes onto chromosomes of the dhole, fennec fox, and gray fox, as well as the mapping of red fox chromosome-specific probes onto chromosomes of the corsac fox. {W}e also present an integrated comparative chromosome map between the species studied here and all canids studied previously. {T}he integrated map demonstrates an extensive conservation of whole chromosome arms across different canid species. {I}n addition, we have generated a comprehensive genome phylogeny for the {C}anidae on the basis of the chromosome rearrangements revealed by comparative painting. {T}his genome phylogeny has provided new insights into the karyotypic relationships among the canids. {O}ur results, together with published data, allow the formulation of a likely {C}anidae ancestral karyotype ({CAK}, 2n=82), and reveal that at least 6-24 chromosomal fission/fusion events are needed to convert the {CAK} karyotype to that of the modern canids.}, keywords = {}, booktitle = {}, journal = {{C}hromosome {R}esearch}, volume = {16}, numero = {1}, pages = {129--143}, ISSN = {0967-3849}, year = {2008}, DOI = {10.1007/s10577-007-1203-5}, URL = {https://www.documentation.ird.fr/hor/fdi:010040978}, }